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Quantum Pi

175,00

Quantum Pi is a concentrated phytonutrient-rich face serum formulated to limit and repair sun-induced skin damage.

Central to its composition is a powerful synergy of 33 of natures’ most photo-resilient botanical and algal extracts to protect the skin against UV and Blue Light damage. Together they form a multi-network photoprotective system to boost the antioxidant capacity of your skin, reduce collagen and elastin degrading enzymes, activate collagen synthesis and increase your skins’ resilience and regenerative capacity.

60 in stock

INGREDIENTS

CITRULLUS LANATUS (Kalahari Melon) SEED OIL*, PUNICA GRANATUM (Pomegranate) SEED OIL*, PRUNUS DOMESTICA (Plum) SEED OIL*, SIMMONDSIA CHINENSIS (Jojoba) SEED OIL*, ORYZA SATIVA (Rice) BRAN EXTRACT*,  RUBUS IDAEUS (Raspberry) SEED EXTRACT*,  PASSIFLORA EDULIS (Passion Fruit) SEED OIL*,  HIPPOPHAE RHAMNOIDES (Sea Buckthorn) FRUIT EXTRACT*, PONGAMIA GLABRA (Karanja) SEED OIL, CANNABIS SATIVA (Hemp) SEED OIL*, EUTERPE OLERACEA (Acai) FRUIT OIL^,  COMMIPHORA MUKUL (Guggul) RESIN EXTRACT*,  CALOPHYLLUM INOPHYLLUM (Tamanu) SEED OIL*,  SAMBUCUS NIGRA (Elderflower) SEED OIL*, OLEA EUROPAEA (Olive) FRUIT OIL*, CAPRYLIC/CAPRIC TRIGLYCERIDE, MAURITIA FLEXUOSA (Buriti) FRUIT OIL^,  SCLEROCARYA BIRREA (Marula) SEED OIL^, KRAMERIA LAPPACEA (Rhatany) ROOT EXTRACT, CAMELLIA SINENSIS (Green Tea) LEAF EXTRACT, BAKUCHIOL, ROSA CANINA (Rosehip) SEED OIL*, CALENDULA OFFICINALIS (Marigold) FLOWER EXTRACT*,  SILYBUM MARIANUM (Milk Thistle) SEED OIL, CURCUMA XANTHORRHIZA (Javanese Turmeric) ROOT EXTRACT*, MAGNOLIA OFFICINALIS (Magnolia) BARK EXTRACT, DUNALIELLA SALINA EXTRACT,  HAEMATOCOCCUS PLUVIALIS (Astaxanthin) EXTRACT, PORPHYRA UMBILICALIS (Nori) EXTRACT*,  NANNOCHLOROPSIS OCULATA EXTRACT, HELIANTHUS ANNUUS (Sunflower) SEED OIL, HUMULUS LUPULUS (Hops) EXTRACT, TOCOPHEROL, ETHYL FERULATE, ROSMARINUS OFFICINALIS (Rosemary) LEAF EXTRACT*

* Organic Ingredients  COSMOS, KOSHER & HALAL CERTIFIED

^ Wild-crafted ingredients 

100% Natural & Vegan

PACKAGING & SIZE

1 fl.oz / 30 ml / Appriximately 3 Month Supply

Packaged in a biophotonic violet glass that prevents decomposition and increases the potency and vitality of the stored compounds.

Keep in a cool, dry place and away from direct sunlight and heat. Do not keen in the fridge as Rice Bran Wax may become solidified in cool temperature.

Patch test prior to use. If irritation occurs discontinue use.

Use within 6 months of opening.

 

REVIEWS

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PHOTOPROTECTION

A multi-networked photo-protective system defends your skin against the damaging effects of UVA, UVB, and Blue Light by limiting the formation of free radicals, by protecting the integrity of your cells as well as your skin’s architecture including collagen, elastin, fibroblast and DNA.

INCREASED SKIN RESILIENCE

Astaxanthin and carotenoid-rich Algal extracts provide antioxidant protection and upregulate genes involved in protecting the cells from oxidative damage and increased resilience to sunlight.

REDUCED APPEARANCE OF WRINKLES

Omega 5, Oryzanol, Resveratrol and Tocotrienols provide powerful collagen and elastin stimulating action to smooth out fine lines and wrinkles, increase skins density and elasticity, giving your skin a soft and supple feel.

INCREASED HYDRATION

Amino acids rich Hemp & Sea buckthorn help increase skins’ hydration and water holding capacity by regenerating the Natural Moisturizing Factor (NMF). Nannochloropsis, Calendula and Raspberry extracts limit the Trans Epidermal Water Loss (TEWL)

EVEN SKIN TONE

Thanks to the powerful synergy of multiple pigmentation reducing compounds Quantum Pi helps even out the skin tone and reduce hyperpigmentation.

The  results

 

These pictures were taken after 3 months of testing Quantum Pi

Because the backs of our hands are one of the most sun exposed areas of our bodies, they often accumulate sun damage at a hight rate. This results in sun spots, decresed skin thickness, loss of elasticity and wrinkles.

SKIN FEEL / SCENT / CONSISTENCY

  • Velvety smooth. Non greasy
  • Warm, Earthy, Herbaceous, Comforting
  • Medium weight liquid. Fast absorbing

      PROPERTIES

      • Fast absorbing and emollient
      • Non-comedogenic
      • Complete cellular nourishment
      • Natural orange hue and a natural scent

      RECOMMENDED FOR

      • All skin types including sensitive skin
      • Fatigued and sun damaged skin
      • Wounds and scars
      • Premature wrinkles and lines
      • Hyperpigmentation and uneven skin tone

      ASTAXANTHIN

      The second-most potent antioxidant known to science with exceptional efficacy in counteracting all categories of photodamages. Extensive studies demonstrate that ASX increases collagen content through the inhibition of MMP-1 and MMP-3 expression in human dermal fibroblast, minimizes DNA damage and influences the kinetics of DNA repair.

      MYCOSPORINE LIKE AMINO ACIDS

      These powerful UV-absorbing compounds inhibit the expression of genes responsible for the degradation of collagen and elastin, while stimulating the production of collagen and elastin in this skin. Additionally MAA’s protect the DNA from UV damage, have an antioxidant and anti-inflammatory activity.

      RESVERATROL

      A natural plant phenol and an antioxidant, studies demonstrate that its photoprotective effect includes protection of the cell membranes, inhibition of sunburnt cells, skin inflammation and UV-induced skin thickening, stimulation of keratinocyte differentiation, increase in collagen and elastin levels, increase in levels of endogenous antioxidants - Superoxide dismutase (SOD) and glutathione

      GAMMA ORYZANOL

      The most potent natural antioxidant in rice, Oryzanol is a multi-compound nutrient made up of a mixture of ferulic acid esters and phytosterols. It has been demonstrated that γ-oryzanol exerts its antioxidant activity at least through three mechanisms: by acting as a free radical scavenger, by boosting our internal antioxidant enzyme activities, and by modulating pathways (Nrf2) involved in gene expressions

      PICEATANNOL

      Piceatannol was found to upregulate the glutathione levels and suppress the UVB-induced generation of reactive oxygen species (ROS) in the keratinocytes. It also promotes collagen production, preventing skin damage and inhibiting pigmentation.

      Frequently Asked Questions

      No. 01

      Is Quantum Pi a Sunscreen?

       

      Quantum Pi is not a sunscreen, but a photoprotective serum. Photoprotection is a multi-network system of sunscreening molecules working in symphony with antioxidants, vitamins, DNA repair enzymes and anti-inflammatory compounds. Just how nature designed it.

      No. 02

      Is it suitable for all skin types?

       

      Quantum Pi is non comedogenic and suitable for all skin types, regardless of gender, age or ethnicity. It is especially suitable for fatigued and sun damaged skin, hyperpigmentation, scars and early signs of aging.

       

      No. 03

      How should I use quantum Pi?

       

      Use 3-4 drops of the serum AM and PM. As it is a waterless formula, apply it to already cleansed and hydrated skin as the last step of your routine.

      Rice bran extract is semisolid under 26 ºC. Do not keep the bottle in the fridge and warm the bottle with your hands to liquify the blend if necessary.

       ingredient research & science

      Quantum Pi has been formulated using the most effective and well studied botanical and algal extracts to support your skins’ innate ability to remain healthy and resilient against environmental stressors, specifically against the damaging effect of UV light.

       

      Haematococcus Pluvialis

      The second strongest naturally occurring antioxidants known to science, Astaxanthin is extracted from the microalgae Haematococcus Pluvialis.

      500 times more potent than vitamin E and 6000 times more than vitamin C, Astaxanthin helps improve wrinkles, age spots and moisture content of the skin.

      Paired with 10-cis and 15-cis beta-carotene extract from Dunaliella Salina, this powerful microalgal duo helps protect the skin from oxidative damage by up-regulating various genes involved in the oxidative stress, DNA repair and reinforcement of the barrier function

       

       

      Source of Astaxanthin, a second-most potent antioxidant known to science with exceptional efficacy in counteracting all categories of photodamages. Extensive studies have shown that ASX increased collagen content through inhibition of MMP-1 and MMP-3 expression in human dermal fibroblast, minimizing DNA damage and influencing the kinetics of DNA repair.

      Nannochloropsis oculata

      A marine-water single-celled algae and a rich source of eicosapentaeneoic acid (EPA), polysacharides and amino acids, zeaxanthin, Vitamin C and B12.

      In studies on human cells is has been shown that it lowers the tyrosinase activity thus preventing hyperpigmentation, increases collagen 1 production, rebuilds barrier fuction and increases the water holding capacity of the skin.

      Additional studies on EPA  have found that topical application of EPA reduced UV-induced epidermal thickening and inhibited collagen decrease induced by UV light by attenuating UV-induced MMP-1 and MMP-9 expression. 

      Moreover, it was found that EPA increased collagen and elastic fibers (tropoelastin and fibrillin-1) expression by increasing transformin growth factor-β expression in aged human skin. Together, these results demonstrate that topical EPA has potential as an anti-skin-aging agent.

      A rich source of eicosapentaenoic acid, polysacharides, amino acids, zeaxanthin, vitamin C and B12. It targets skin hydration and barrier function. It re-equilibrates lipid deficient skin and reduces the Trans Epidermal Water Loss (TEWL) while decreasing desquamation

      POMEGRANATE SEED OIL

      The richest source of vitamin E and Omega 5 fatty acids, its powerful anti-aging effect on the skin is expressed in increased collagen production, improved skins’ elasticity and density

      Key benefits

      1. increases skins’ elasticity and density by stimulating the synthesis of collagen and elastin fibers.
      2. restores skins’ barrier function
      3. eliminates free radicals and inflammatory enzymes that cause cellular degradation and premature ageing
      4. modulates the expression of genes involved in the determination of skin quality (strength, elasticity, firmness)
      5.  protects against UV-induced skin and DNA damage.

      The richest source of vitamin E and Omega 5 fatty acids, its powerful anti-aging effect on the skin is expressed in increased collagen production, improved skins’ elasticity and density

      SEABUCKTHORN BERRY EXTRACT

      The components of Seabuckthorn pulp extract are different to that of seeds, as it is the fruit pulp that contains the rare Omega 7 fatty acid. This makes the fruit pulp uniquely suitable to treat sunburn, rebuild damaged skin and support wound healing and regeneration.

      • Sea buckthorn Berry Oil Phytonutrient Content
      • Over 190 identified bioactive compounds
      • Rich in rare Palmitoleic acid (Omega 7) as well as Omega 3, 6 and 9.
      • Contains fat and water soluble form of Vitamin C with levels up to 15 times that of an orange
      • Superoxide Dismutase (SOD) – one of the most important force against oxidation in the human body
      • Vitamin A precursor: that is alpha- and beta-carotene, other carotenoids: lycopene, cryptoxanthin, physalien, zeaxanthin
      • Vitamin E (α- tocopherol, γ-tocopherol) and tocotrienol
      • Vitamins B1, B2, B6, K and P and D
      • 11 mineral salts, including zinc, iron, calcium, selenium, copper
      • 18 amino acids
      • Phytosterols: such as cholesterol, campesterol, stigmasterol and β-sitosterol
      • Flavonoids found in the largest quantity: isorhamnetin, followed by isorham-netin-3-O-13-D-glucoside, rutin, quercetin, myricetin and kaempferol

      Rich in rare Omega 7 and 190 identified nutrients, this extract is one of the most complex and beneficial ingredients in skincare. Uniquely suitable to treat sunburn, rebuild damaged skin and support wound healing and regeneration.

      HEMP SEED OIL

      Containing over 400 identified bioactive substances, Cannabis Sativa is arguably one of the most studied plants in human history. Rich in wide variety of cannabinoids, vitamins, minerals and amino acids, this is a skin nutritional powerhouse.

      With a comedogenic rating of zero and the perfect ratio of Omega 6 to 3, the hemp seed oil is nourishing and revitalizing for the skin.

      The amino acid content helps to replenish the Natural Moisturising Factor within the skin, increasing its water-holding capacity over time.

      Cannabinoid profiling studies have shown that hemp seed oil contains 32 different phytocannabinoids including 22 of significance: 32, CBD, CBDA, CBGA-C4, CBEA, CBCT, CBDVA, THC, THCA, CBDV, CBN, CBMA, CBCA, CBDA-C4, CBTA, CBNA, CBT, 6,7-epoxy-CBG, CBG, THCA-C1, CBD-C4, CBCV and THCV

      Aboundant in Phytocannabinoids that soothe inflammaroty skin reactions and amino acids which help replenish the Natural Moisturising Factor within the skin, increasing its water-holding capacity and hydration. 

      JAVANESE TURMERIC

      “Matrix metalloproteinases (MMPs) are key regulators of the skin photoaging process that is set in motion by exposure to ultraviolet (UV) irradiation. This skin damage results from UV-induced generation of reactive oxygen species, which are associated with upregulation of MMPs and decreased collagen synthesis. We investigated the effects of xanthorrhizol, isolated from Curcuma xanthorrhiza, on the expression of MMP-1 and type-I procollagen in UV-irradiated human skin fibroblasts. Fibroblasts cultured in the presence or absence of purified xanthorrhizol or C. xanthorrhiza extract were irradiated with UV (20 mJ/cm(2)), and MMP-1 and type-I procollagen levels were measured using Western blot analysis. Xanthorrhizol (0.001-0.1 microM) and C. xanthorrhiza extract (0.01-0.5 microg/mL) induced a significant, dose-dependent decrease in the expression of MMP-1 protein, and increased the expression of type-1 procollagen. At a concentration of 0.1 microM, xanthorrhizol nearly completely abrogated MMP-1 expression. The MMP-1-suppressing and type-1 procollagen-inducing effects of xanthorrhizol treatment were greater than those of epigallocatechin 3-O-gallate (EGCG), which is known to be a natural anti-aging agent. These results suggest that xanthorrhizol is a potential candidate for the prevention and treatment of skin aging.”

      6.1. Terpenoids

      Various studies have shown that C. xanthorrhiza contains a variety of terpenoids, especially bisabolane sesquiterpenoids. Earlier, at least 50 bisabolane sesquiterpenes were discovered from the genus Curcuma, particularly its turmeric rhizome [61]. Sesquiterpene compounds that have been successfully isolated and characterized from C. xanthorrhiza are bisacurone, bisacumol, bisacurol, curlone [62], α-curcumene, ar-turmerone, xanthorrhizol, germacrone, β-curcumene, β-sesquiphellandrene, curzerenone, α-turmerone, β-turmerone [62], (7R,10R)-10,11-dihydro-10,11-dihydroxy-xanthorrhizol 3-Oβ-D-glucopyranoside, (-)-curcuhydroquinone 2,5-di-Oβ-D-glucopyranoside, 13-hydroxy-xanthorrhizol, 12,13-epoxy-xanthorrhizol, β-bisabolol [61], zedoardiol, 3,4-dihydroxybisabola-1,10-diene, zedoarol, guaia-1(10),3,5,7(11),8-pentaene-2-on-12,8-olide, zederone, curcumenone [21], zedoaraldehyde, gweicurculactone, 13-hydroxygermacrone, germacrone, gelchomanolide, and 8β-hydroxy-isogermafurenolide [63]. In addition to sesquiterpenes, C. xanthorrhiza also contains monoterpene which has been successfully isolated, namely, camphor [19].

       

      6.2. Curcuminoids

      Curcuminoids are natural polyphenol compounds with a linear diarylheptanoid structure. A curcuminoid of C. xanthorrhiza mostly consists of dicinnamoylmethane derivatives. Various curcuminoids have been successfully obtained and categorized from the rhizome of C. xanthorrhiza such as octahydrocurcumin, 1-hydroxy-1,7-bis(4-hydroxy-3-methoxypheny1)-6-heptene-3,5-dione, dihydrocurcumin, hexahydrocurcumin, curcumin [62], monodemethoxy curcumin, bis-demethoxy curcumin [19], 1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,4-dione [13], 3-demethoxycyclocurcumin, and 1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-diol [60].

      6.3. Other Phenolic Compounds

      In addition to terpenoids and curcuminoids, several other chemical compounds have also been successfully detected in the rhizome of C. xanthorrhiza such as vanillin [21], 3-hydroxy-6-methylacetophenone, and dehydro-6-gingerdione [63]. However, 13-hydroxy-xanthorrhizol and 12,13-epoxy-xanthorrhizol were identified beforehand from Curcuma longa rhizomes. Meanwhile, 3-hydroxy-6-methylacetophenone alluded as a residual product of synthetic reactions [64, 65], but Zhang et al. [63] found it for the first time as a nature-derived metabolite. Moreover, Zhang et al. [63] also announced the first identification of dehydro-6-gingerdione from C. xanthorrhiza, which was previously isolated from Zingiber officinale [66].

      Mostly, the active compounds above were isolated from the rhizome of C. xanthorrhiza. However, other parts of C. xanthorrhiza are also probably containing a variety of important secondary metabolites, for example, the flower bract, which is proven to contain several active compounds, namely, xanthorrhizol (16.13%), α-curcumene (15.12%), β-elements (4.60%), trans-caryophyllene (3.48%), β-farnesene (0.29%), camphor (0.21%), and isoborneol (0.04%) [47].

      Xanthorrhizol a compound unique to this tropical, high altitude  Javanes Turmeric variety has been shown to restrict the production of MMPs – enzymes that break down the collagen and elastin. It also stimulater the production of pro collagen 1. 

      GREEN TEA EXTRACT

      The major green tea catechins are (-)-epigallocatechin-3-gallate (EGCG; 9-13%), (-)-epigallocatechin (EGC; 3-6%), (-)-epicatechin-3-gallate (ECG; 3-6%), (-)-epicatechin (EC; 1-3%), and (+)-catechin (C; less than 1%). Several catechins found in green tea have been shown to have antioxidant activities [14;15] and display cutaneous photoprotection [16]. A previous study showed that the galloyl catechins, especially EGCG, are an effective protectant against the oxidative stress of UVB radiation [17]. Topical treatment of mouse and human skin with EGCG before UV exposure significantly reduced UVB-induced erythema development, hydrogen peroxide production and leukocyte infiltration [18;19]. In addition, EGCG have been shown to protect against UVB-induced skin carcinogenesis in mice [20-22]. These data suggest that the galloylcatechins have the potential to reduce the risk of UV-induced, oxidative stress-mediated skin diseases in humans. Although ECG is the third major catechin in green tea, it shows strong biological activity in several areas [23]. It was reported that EGCG and ECG have anticancer activities, but not EGC or EC. Thus, both EGCG and ECG may play an important role in green tea-induced anti-tumorigenesis [23]. Recently, our laboratory demonstrated that ECG protects skin cells against UVA-induced damage [24]. However, ECG has not been studied in detail regarding UVB photoprotection. Several studies have shown that EGCG are photoprotectant in skin cells, but little input has been directed to evaluating the photoprotective effects by ECG. In this study, effect of ECG on UVB-induced skin cell damage was investigated. Our results indicate that ECG may act through inhibition of UVB-induced intracellular hydrogen peroxide production and MAPK signaling pathway

      Wildly studied ECG and ECGC were shown to protect keratinocytes against UVB-induced damage by inhibiting intracellular H2O2 generation, lipid peroxidation and MAPKs activation.

      DUNALIELLA SALINA

      Beta-carotene rich Dunaliella Salina and helps reinforce the skin’ defence mechanisms by up regulating various genes involved in the oxidative stress, DNA repair, the antimicrobial defence and the reinforcement of the barrier function.

       

      This extraordinary alga is one of the most environmentally tolerant eukaryotic organisms known. Its ability to survive extreme salinity 3 to 31% NaCI saturation, wide temperature ranges from < 0 °Cto > 38 °C and extreme pH tolerance range from pH 1 to 11 is understood to be thanks to the photoprotective role of beta carotene and glycerol the algae produces when under stress.

      RICE BRAN C02 EXTRACT

      Highly photoprotective and rich in powerful tocotrienols and gamma-oryzanol, rice bran extract helps to reduce wrinkles, improve skin hydration, thickness and elasticity.

      In summary, Rice Bran Oil has been shown to:

      • Protect the skin from UV caused sunburn and skin damage
      • Dramatically improve wrinkles, skin thickness and elasticity
      • Even out the skin tone and reduce hyperpigmentation
      • Increase moisture retention and cellular skin hydration level
      • Protect cellular membranes from oxidative damage
      • Stimulate collagen production and reduce collagen degrading enzymes
      • Reduce skin inflammation and improve condition such as atopic dermatitis

      The most potent natural antioxidant in rice, Oryzanol is a multi-compound nutrient made up of a mixture of ferulic acid esters and phytosterols. It has been demonstrated that γ-oryzanol acts as a free radical scavenger, boosts our internal antioxidant enzyme activities, and modulates (Nrf2) pathways involved in gene expressions.

      JOJOBA OIL

      Sinking effortlessly into the skin Jojoba Oil unlike other plant seed oils, is composed from wax esters and is the only non-triglyceride of all vegetable or animal oils except that from the sperm whale.

      It consists of 98-100% cis-monounsaturated liquid esters. Thanks to this jojoba oil is very stable and resistant to oxidation.

      Extensive studies on Jojoba oil showed a wide range of pharmacological applications, including antioxidant, anti-acne and antipsoriasis, anti-inflammatory, antifungal, antipyretic, analgesic, antimicrobial, and anti-hyperglycemia activities.

      Skin indentation tests showed that the oil enhanced skin elasticity, restore the skin’s natural shine.

      Jojoba contains Vitamin D and A, α, γ, and δ tocopherols as well as sterols and flavonoids.

      Ten flavonoids have been identified as quercetin quercetin 3′methyl ether (isorhamnetin), quercetin 3-methyl ether, quercetin 3,3′-dimethyl ether isorhamnetin 3-O-glucoside, quercetin 3-O-glucoside, typhaneoside, isorhamnetin 3-O-rutinoside , quercetin 3-O-rutinoside.

      Composed of liquid wax, jojoba is the only non-triglyceride of all vegetable or animal oils except that from the sperm whale making it very stable and resistant to oxidation. Jojoba balances sebum production, enhances skin elasticity and restored its natural shine.

       

      RASPBERRY CO2 EXTRACT

      Remarkably helpful in maintaining healthy skin, supporting skin elasticity, soothing problem skin, minimizing the appearance of wrinkles and supporting those with maturing skin.

      Constituents:

      Polyphenol compounds: phytosterols: campesterol, stigmasterol, sitosterol, avenasterol, cytrostadienol, carotenoids: zeaxanthin, β-carotene, lutein and cryptoxanthin
      vitamin E (301.9 mg·100g-1); tocopherols (295.19 mg·100 g-1), including α-tocopherol (71 mg·100 g-1), γ-tocopherol (272 mg·100g-1),
      Δ- tocopherol (17.4 mg·100 g-1); and tocotrienols (6.73 mg·100 g-1)

       

      Remarkably helpful in maintaining healthy skin, supporting skin elasticity, soothing problem skin, minimizing the appearance of wrinkles and supporting those with maturing skin.

      ROSEMARY CO2 EXTRACT

      Rosemary diterpenes exhibited cellular photoprotective effects and mitochondrial membrane potential restoration, as well as an enhanced capacity to decrease DNA double strand breaks and the DNA damage response.

      Rosemary diterpenes ensure cellular photoprotection and decrease DNA double strand breaks.

      MAGNOLIA BARK EXTRACT

      Magnolol inhibited proliferation of human malignant melanoma cells. 

      “Magnolol inhibited proliferation of human malignant melanoma A375-S2 cells. The drug induced oligonucleosomal fragmentation of DNA in A375-S2 cells and increased caspase-3, 8, 9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase dependent DNase (ICAD) and poly-(ADP-ribose) polymerase (PARP). Pan-caspase inhibitor (z-VADfmk), caspase-3 inhibitor (z-DEVD-fmk), capase-8 inhibitor (z-IETD-fmk), caspase-9 inhibitor (z-LEHD-fmk) and caspase-10 inhibitor (z-AEVD-fmk) inhibited magnolol-induced A375-S2 cell apoptosis. The level of anti-apoptotic mitochondrial protein Bcl-2 was up-regulated while the level of pro-apoptotic protein Bax was down-regulated. Taken together, our results indicate that magnolol induces apoptosis by activation of both mitochondrial and death receptor pathways in A375-S2 cells.”

      “Honokiol and magnolol have shown strong antioxidative, anti-inflammatory, anti-tumor, and anti-microbial properties mediated by several modes of action. Thus, honokiol and magnolol exhibit a desirable spectrum of bioavailability rather than other natural products. To fully realize the potential of honokiol and magnolol, clinical trials are needed. Honokiol and magnolol analogues with improved pharmacokinetic and pharmacodynamics will also make the field move forward. Safety during long-term administration, combined with its cost and future therapeutic potential, makes it an ideal agent for both prevention and therapy in dermatology either alone or in combination with other drugs. This knowledge is required for the development of future analogues, which may target either of these pathways, and for the development of clinical trials using honokiol and magnolol or their analogues. Further insights into the signaling network and interaction points modulated by honokiol and magnolol may provide the basis for novel discovery programs to exploit honokiol and magnolol for the prevention and treatment of dermatologic disorders.”

      Magnolol and Honokiol the most bilogicaly active compounds with antibacterial and anti-inflammatory properties, especially effective against against acne-causing germs without irritating the skin. 

      ROSEHIP C02 EXTRACT

      Rosehip 

      HOPS EXTRACT

      Hops inhibits the MMP9 enzyme, also known as matrix metalloproteinase, one culprit of the deterioration of the connective tissue. In addition, it boosts the production of new connective tissue fibers, such as elastin und fibrillin.

      Due to the presence of phytohormones hops extract has a stimulating effect on the collagen production by stimulates skin circulation. Its anti-inflammatory effects are used in cosmetics and help nervous and over-sensitized skin to recover. 

      Its antioxidant and oestrogen-like properties help to alleviate inflammations and invigorate the connective tissue.

      Hops inhibits the MMP9 enzyme, one culprit of the deterioration of the connective tissue. Phytohormones in Hops Extract stimulate collagen production and cellular regeneration by boosting the production of new connective tissue fibers, such as elastin und fibrillin.

      PORPHYRA UMBILICALIS

      Found in the intertidal shores and highly exposed to UV radiation, Porphyra Umbilicalis, commonly known as Nori is a source of mycosporine-like amino acids (MAAs). MAAs are commonly found in marine organisms exposed to intense UV stress, where they act as sunscreening compounds, typically absorbing between 310 nm and 360 nm.

      In studies on human cells MAA’s have been shown to protect keratinocytes and fibroblast during UV stress and 24 hours after, maintaining the integrity of the cells and their components such as lipid membrane and DNA.

      Additionally these compounds inhibit the expression of genes responsible for the degradation of collagen and elastin while stimulating the production of collagen and elastin in this skin.

      MAAs can be synthesized through the conjugation of amino acids and the resultant MAA structural core is so primitive that the MAAs are considered to be potential molecular pioneers among natural sunscreens.

      Source of mycosporine-like amino acids (MAAs) considered to be one of the most powerful UVA screening compounds known to science. These UV-absorbing compounds inhibit the expression of genes responsible for the degradation of collagen and elastin, while stimulating its production in this skin. Additionally MAA’s protect the DNA from UV damage, have an antioxidant and anti-inflammatory activity.

      MILK THISTLE

      Silymarin – a polyphenolic flavonoid antioxidant found in Milk Thistle is the main active ingredient responsible for the photoprotective effect.

      Recent studies showed that silymarin constituents could strongly protect against photocarcinogenesis and inhibit UVB and chemical tumor promoter-induced skin inflammation and edema. Silymarin also attenuates UVA-induced damage to human keratinocytes.

      Animal and cell culture studies have shown that silymarin exhibits preventive and anticancer effects against skin cancer. For example, silymarin strongly prevents both photocarcinogenesis and skin tumor promotion by scavenging free radicals and reactive oxygen species and strengthening the antioxidant system.  Silymarin inhibits endogenous tumor promoter tumor necrosis factor alpha in mouse skin, a central mediator in skin tumor promotion. In mechanistic studies, silymarin inhibits mitogenic and cell survival signaling and induces apoptosis. Furthermore, silymarin effectively modulates cell-cycle regulators and check points toward inhibition of proliferation, and growth arrest in G0-G1 and G2-M phases of the cell cycle. Thus, due to its mechanism-based chemopreventive and anticancer effects in experimental models, silymarin is an important candidate for the prevention and/or therapy of skin cancer, as well as other cancers of epithelial origin in humans.

      Extensively studied Silymarin and Silybin significantly reduce Single Strand DNA Breaks (SSB), reduce the production of ROS, prevent depletion of GSH the most important cellular non-enzymatic antioxidant.

      PASSION FRUIT OIL

      Resveratrol and Piceatannol are two molecules in Passion Fruit Seed Oil responsible for the anti-photoageing effect. Piceatannol was found to upregulate the glutathion levels and suppress the UVB-induced generation of reactive oxygen species (ROS) in the keratinocytes. It also promotes collagen production, preventing skin damage and inhibiting pigmentation.

       

      Resveratrol and Piceannatol protect from UV induced skin damage: promote collagen production, and inhibits hyper pigmentation.

      PONGAMIA GLABRA

      Pongamol and karanjin are two major bioactive compounds isolated from Pongamia species exhibiting strong  UV-A and UV-B screening activity.

      Pongamol a furanoflavone protects against UVA and karanjin derivative of phenolic acid protect against UVB.

      Pongamol and karanjin are two compounds responsible for the powerful UV-A and UV-B screening activity.

      CALENDULA CO2 EXTRACT

      Calendula extracts stimulate granulation, enhance formation of cell tissue, accelerate wound healing and have anti-inflammatory and pain killing effects.

      The anti-inflammatory and cancer-preventing efficacy of calendula officinalis is related to the activity of triterpene alcohols, especially to faradiol esters, taraxasterol, amyrins and lupeol.

      Coumarins: Esculetin, Scopoletin, P Coumaric Acid, 7-hydroxy Coumarin reduce the inflammatory markers.

      Quercetin, Isorhamertin have been shown to block activation of inflammatory enzymes stopping collagen break down.

      Faradiol esters have a significant anti-inflammatory effect. Marigold flower CO2-extracts are recommended for treatment of hurts, bruises, inflammations and damaged skin, for wound healing, for dry sensitive skin.

      Anti-inflammatory mechanisms which play an important role in anticarcinogenic activity include inhibition of NF-kappa B, COX-2, arachidonic acid metabolism, decreased expression of inflammatory cytokines IL-1 beta, IL-6, and TNF alpha, resulting in growth inhibition of cancer cell lines and down-regulation of enzymes, such as protein kinase C which mediates inflammation and tumour-cell proliferation.

      The product has also a relatively high concentration of phytosterols which stimulate the collagen synthesis and thus help to protect the skin against harmful environmental stress. A recent human study confirmed the photoprotective effect of phytosterols. It has been demonstrated that phytosterols inhibit UV-induced MMP-1 expression and downregulation of COL1A1 and COL1A2 genes responsible for collagen synthesis.

         

        Remarkably healing, calendula extract stimulates granulation, accelerating wound healing and enhancing tissue regeneration. It prevents cellular water loss and offers strong protection against UVA, UVB and Blue Light

        ELDERBERRY SEED OIL

        Protection against UV radiation

        Polyphenols have the ability to protect against UV radiation and its negative consequences (Nichols & Katiyar, 2010). The extract from elderberry fruits was used to produce an emulsion that protects against solar radiation, which was characterized by the favourable value of sun protection factor, SPF = 9.88, UVA protection factor, PF-UVA = 5.18, UVA/UVB = 0.73; critical wavelength, λc = 376.5 nm and photostability expressed in % SPF = 87.07 and % PF-UVA = 92.05. The effectiveness of this preparation was higher as compared to filters used in commercial products available on the market; additionally, synergism of elderberry extract with extracts of Helichrysum arenarium and Crataegus monogyna was also demonstrated (Jarzycka, Lewińska, Gancarz, & Wilk, 2013). Elderberry flowers are potential sources of active substances, which in contrast to the antioxidants commonly added to cosmetics, are not subjected to degradation under the influence of UVR and exhibit a high biological activity (Chen, Hu, & Wang, 2012).

        Among tocopherols in elderberry seed oil, α-tocopherol and γ-tocopherol were detected at 0.49 and 2.63 µg/g oil (Fazio et al., 2013), while the residues after pressing of oil from seeds contained α-, β-, γ- and δ-tocopherols (0.96, 0.31, 12.44 and 0.16 mg/100 g respectively) and α-tocotrienol (0.89 mg/100 g) 

        PLUM SEED OIL

        Luxurious in texture and fast-absorbing, Plum Oil helps to brighten and balance your skin,  aiding the restoration of barrier function and moisture retention for a soft, youthful glow.

        Luxurious in texture and fast-absorbing, Plum Oil helps to brighten and balance your skin,  aiding the restoration of barrier function and moisture retention for a soft, youthful glow.

        Your skin is not a cover, it is an intelligent, living  organ that enables your biology for a biodynamic communication with the environment.

        What we put on our skin impacts our biology. Not only that, it impacts the whole ecosystems, it impacts our planet. The products we purchase is the industry we inadvertently support and finance.

        In many cases, these industries exploit Earth’s resources, destroy ecosystems, pollute and poison the environment, poison us. Ultimately how we treat our plant we treat ourselves.